Introduction
Cartilage has many functions, including the ability to resist compressive forces, enhance bone resilience, and provide support on bony areas where there is a need for flexibility. The primary cell that makes cartilage is the chondrocyte, which resides within the lacunae. The matrix of cartilageconsists of fibrous tissue and various combinations of proteoglycans and glycosaminoglycans. Cartilage, once synthesized, lacks lymphatic or blood supply and the movement of waste and nutrition is chiefly via diffusion to and from adjacent tissues. Cartilage, like bone, is surrounded by a perichondrium-like fibrous membrane. This layer is notefficient at regenerating cartilage. Hence, its recovery is slow after injury. The lack of active blood flow is the major reason any injury to cartilage takes a long time to heal. Cartilage has no nerve innervation, and hence there is no sensation when it is injured or damaged. When there is calcification of cartilage, the chondrocytes die. This is followed by the replacement of cartilage with bone-like tissue. Unlike bone, cartilage does not have calcium in the matrix. Instead, it contains high amounts of chondroitin, which is the material that provides elasticity and flexibility.
Structure and Function
Several types of cartilage are found in the human body, and their structure and relevant function depend on this variation.
Hyaline Cartilage
Hyaline cartilage is the most copioustype of cartilage in the human body.[1]It has a pale blue-white color and is smooth to the touch. It is primarily composed of type II collagen and proteoglycans. The surface is usually moist, but with age, the cartilage becomes dry, thinner, and moreyellow. Hyaline cartilage is usually found in the trachea, nose, epiphyseal growth plate, sternum, and ventral segments of the ribs. Hyaline cartilage produces a resilient surface with minimalfriction. It also has an excellent ability to resist compressive forces at sites of bone articulation.[2]
Elastic Cartilage
This cartilage appears a dull yellow and is most commonly found in the larynx, ear, epiglottis, and eustachian tube. A perichondrium-like layer also surrounds it. It provides flexibility and is resilient to pressure.[3]
Fibrocartilage
This is abundant in type 1 collagen and contains significantlyless proteoglycan than hyaline cartilage. It can resist high degrees of tension and compression. It is commonly found in tendons, ligaments, intervertebral discs, articular surfaces of some bones, and in menisci. Unlike other cartilage, it has no perichondrium.[4]
Embryology
Cartilage is formed from the mesoderm germ layer by the process known as chondrogenesis.[5]Mesenchyme differentiates into chondroblasts, which are the cells that secrete the major components of the extracellular matrix—the most important of these components for cartilage formation being aggrecan and type II collagen. Once initial chondrification occurs, the immature cartilage grows mainly by developing into a more mature state since it cannot grow by mitosis. There is minimal cell division in cartilage; therefore, the size and mass of cartilage do not change significantly after initially chondrification.
Blood Supply and Lymphatics
Cartilage is avascular. This characteristic of cartilage is paramount during the discussion and management of diseases affecting cartilage. Since there is no direct blood supply, chondrocytes receive nourishment via diffusion from the surrounding environment. The compressive forces that regularly act on cartilage also increase the diffusion of nutrients. This indirect process of receiving nutrients is a major factor in the slow turnover of the extracellular matrix and lack of repair seen in cartilage.
Nerves
Cartilage does not contain nerves; it is aneural.[6]If any pain is associated with a pathology involving cartilage, it is most commonly due to irritation of surrounding structures, such as inflammation of the joint and bone in osteoarthritis.
Muscles
Fibrocartilage is a major component of entheses, defined as the connective tissue between muscle tendon or ligament and bone. The fibrocartilaginous enthesis consists of 4 transition zones as it progresses from tendon to bone.[7]These transition zones are listed in order ofprogression from muscle to bone.
Longitudinal fibroblasts and a parallel arrangement of collagen fibers are found in the tendinous area
A fibrocartilaginous region where the main type ofcells present transitions from fibroblast to chondrocytes
A region called the "blue line" or "tide mark" due to an abrupt transition from cartilaginous to calcified fibrocartilage
Bone
Physiologic Variants
Literature shows many anatomical variants of cartilage, and in many cases, this can affect the pathology associated. For example, a study showed a significant correlation between novel genetic variants in cartilage thickness and the incidence of hip osteoarthritis.[8]
Clinical Significance
An immense variety of clinical pathology exists involving cartilage, such as osteoarthritis, spinal disc herniation, traumatic rupture/detachment, achondroplasia, costochondritis, and neoplasm, and many others. These result from a variety ofdegenerative, inflammatory, and congenitalcauses.
Osteoarthritis is a disease affecting the whole joint; however,the articular cartilage (a subset of hyaline cartilage) within the joint is the most affected tissue. Osteoarthritis is known as a "wear and tear" phenomenon due to it mainly affecting joints under higher amounts of stress. It results due to articular cartilage being thinned and wearing away. This ultimately results in a decreased range of motion, "bone against bone" contact within the joint, and pain. The initial clinical treatment is with anti-inflammatories and corticosteroid injections intraarticularly. Both therapies function to reduce the inflammatory reaction caused by the degenerative cartilage's release of cytokines. Patients may alsoshow improvement by losing weight, exercising, and efforts to decrease joint stress with rest andusing a cane.Eventually,however, many patients will develop pain and symptoms that interfere with daily life. At this point,joint replacement or resurfacing may be recommended. Arthroscopic surgery is no longer recommended as it does not improve outcomes in knee osteoarthritis and can cause harm.
Another common degenerative disease of cartilage is spinal disc herniation. It is due to degenerative changes of the outer ring of the intervertebral disc, called the annulus fibrosus. Theannulusfibrosusis composed of fibrocartilage. Trauma, straining, and lifting injuries are also implicated in the weakening of the annulus fibrosis predisposing to disc herniation. When there is structural damage to the annulus fibrosus, the nucleus pulposus contained within the disc may herniate into the spinal canal, causing impingement of 1 or multiple nervesas well as induce inflammatory changes due to the damaged fibrocartilage.[9]Diagnosis is made by history, symptoms, and physical examination. At some point in the evaluation, imaging studies are usually conducted to rule out other causes such as tumors, spondylolisthesis, and space-occupying lesions. Although some patients warrant surgery due to the severity of symptoms, most cases do not require surgical intervention as they resolve with conservative measures such as anti-inflammatories and lifestyle changes for the patient.
In contrast to the degenerative diseases of cartilage, Achondroplasia is a genetic disorder of cartilage formation and is the most common cause of dwarfism. The pathology seen is due to a mutation on chromosome 4 affect the fibroblast growth factor receptor 3 (FGFR3) gene, which normally functions as a negative regulator of bone and cartilage growth. The mutation in achondroplasia results in a truncated dysfunctional protein that is constitutively active. These dysfunctional proteins impede cartilage growth and development by suppressing chondrocyte proliferation and calcification.[10] The diagnosis of achondroplasia is usually during pregnancy via prenatal ultrasound. There is currentlyno known cure for achondroplasia as it is not affected by a hormone pathway that can be pharmacologically manipulated, and corrective surgery is controversial.[11]
Figure
Cartilage and Bone Illustration Contributed by Beckie Palmer
Figure
Triangular Fibro Cartilage Complex Contributed by Katherine Humphries
Figure
Earlobe, cartilage, soft tissue and cutis of the external ear. H/E 4x Contributed by Fabiola Farci, MD
Figure
Cartilage, H/E 20x Contributed by Fabiola Farci, MD
Figure
Cartilage and nerves, H/E 4x Contributed by Fabiola Farci, MD
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Disclosure: Lou-Ren Chang declares no relevant financial relationships with ineligible companies.
Disclosure: Geoffrey Marston declares no relevant financial relationships with ineligible companies.
Disclosure: Andrew Martin declares no relevant financial relationships with ineligible companies.
